Lines of research Erythrocytosis - Instituto Biología Celular

Lines of research
Erythrocytosis

1. Characterization of High Altitude Pathological Erythrocytosis

Biocellular and biomolecular characterization of High Altitude Pathological Erythrocytosis in Bolivian Andeans.
Differential diagnosis of High Altitude Pathological Erythrocytosis from other erythrocytosis of clinical relevance such as Secondary Erythrocytosis and Polycythemia Vera.
Determination of hematological values at high altitude.

Publications

Novel form of alternative splicing of NFKB1. Its role in adaptation to high altitude in Andean Aymara, 2018.
Tibetan enriched PKLR variant is beneficial to high altitude adaption by improving oxygen delivery, 2018.
Hematolgical values in pregnant women at high altitude, 2018.
Clinical characterization of High Altitude Pathological Erythrocytosis, 2016.
Bolivian aymaras natives with Chronic Mountain Sickness have autonomous BFU-E growth, 2015.
High Altitude Pathological Erythrocytosis: biological characterization, diagnosis and treatment, 2013.
Hematopoietic progenitor cells in CMS show hypersensitivity to Epo and Inhibition by statins, 2009.

2. Genetic adaptation to high altitude

Identification of genes involved in the adaptation to high altitude.
Identification of genetic alterations in Andean inhabitants.
Identification of the molecular mechanism to high altitude adaptation.

Publications

3. Pharmacological treatment of pathological erythrocytosis

Guidelines for the pharmacological treatment of pathological erythrocytosis at high altitude.

Publications